Publicaciones
UNIDAD DE MEJORA GENÉTICA DE ORGANISMOS FOTOSINTÉTICOS
Menú laboratorio
PUBLICACIONES INTERNACIONALES
2023
1. Anne Rolton, Stephen Charles Webb, Monserrat López-Sanmartín, Kate Suzanne Hutson. Bivalve digestive epithelial virosis (DEV): A cause of disease or a natural process?. Journal of Invertebrate Pathology 198 (2023) 107924. https://doi.org/10.1016/j.jip.2023.107924
2. Antonio León-Vaz, Inmaculada Giráldez, Ignacio Moreno-Garrido, Joao Varela, Javier Vigara, Rosa León, José Pedro Cañavate. Amino acids profile of 56 species of microalgae reveals that free amino acids allow to distinguish between phylogenetic groups. Algal Research 74 (2023) 103181. https://doi.org/10.1016/j.algal.2023.103181
3. Antonio León-Vaz, Rosa León, Javier Vigara, Christiane Funk. Exploring Nordic microalgae as a potential novel source of antioxidant and bioactive compounds. New Biotechnology. 73 (25) 2023, 1-8. https://doi.org/10.1016/j.nbt.2022.12.001
4. Antonio Leon-Vaz, Juan Cubero-Cardoso, Angeles Trujillo-Reyes C, Fernando G. Fermoso, Rosa León, Christiane Funk, Javier Vigara, Juan Urbano. Enhanced wastewater bioremediation by a sulfur-based copolymer as scaffold for microalgae immobilization (AlgaPol). Chemosphere 315 (2023) 137761. https://doi.org/10.1016/j.chemosphere.2023.137761
5. Monserrat López-Sanmartín, Rocío Rengel, Manuel López-López, Antonio J. Lebrón, Ana Molina-Márquez, Ignacio de la Rosa, Pilar López-Cornejo, Alberto Cuesta, Javier Vigara, Rosa León. D-Amino acid peptides as antimicrobial agents against vibrio-associated diseases I aquaculture. Aquaculture. Volume 569, 2023, 739362. https://doi.org/10.1016/j.aquaculture.2023.739362
6. Chazan A, Das I, Fujiwara T, Murakoshi S, Rozenberg A, Molina-Márquez A, K. San F.K., Tatsuki Tanaka T, Gómez-Villegas P, Larom S, Pushkarev A, Malakar P, Hasegawa M, Tsukamoto Y, Ishizuka T, Konno M, Nagata T, Mizuno Y, Katayama K, Abe-Yoshizumi R, Ruhman S, Inoue K, Kandori H, León R., Shihoya W, Yoshizawa S, Sheves M, Nureki O, and Béjà O. Energy transfer in ubiquitous rhodopsin pumps with xanthophyll antennas. Nature. 2023 (In press). (69.5, D1). https://doi.org/10.1038/s41586-023-05774-6. URL: https://www.nature.com/articles/s41586-023-05774-6
7. David Pérez a, María Luisa Moyá a, María Bautista b, Rosa León d, Ana Molina-Márquez d, Marta Vila d, Lucía Romero-Azogil c, Elena Benito c, María de Gracia García-Martín c, Paula Moreno-Gordillo f, Iván V. Rosado f, Fernando R. Balestra e, Pablo Huertas e, Manuel López-López b, Pilar López-Cornejo. A novel biocompatible polymer derived from D-Mannitol used as a vector in the field of genetic engineering of Eukarytic cells. Colloids Surf. B., 224, 113219(1)-3219(9). https://doi.org/10.1016/j.colsurfb.2023.113219
8. Javier Ávila-Román. Patricia Gómez-Villegas, Carla C. C. R. de Carvalho, Javier Vigara. Virginia Motilva. Rosa León, Elena Talero Up-Regulation of the Nrf2/HO-1 Antioxidant Pathway in Macrophages by an Extract from a New Halophilic Archaea Isolated in Odiel Saltworks. Antioxidants 2023, 12(5), 1080; https://doi.org/10.3390/antiox12051080
9. Paula Mapelli-Brahm, Patricia Gómez-Villegas, Mariana Lourdes Gonda, Antonio León-Vaz, Rosa León, Jennifer Mildenberger, Céline Rebours,Verónica Saravia, Silvana Vero,Eugenia Vila and Antonio J. Meléndez-Martínez. Microalgae, Seaweeds and Aquatic Bacteria, Archaea, and Yeasts: Sources of Carotenoids with Potential Antioxidant and Anti-Inflammatory Health-Promoting Actions in the Sustainability Era. Mar. Drugs 2023, 21(6), 340; https://doi.org/10.3390/md21060340
2022
1. Patricia Gómez-Villegas, José Luis Guerrero, Miguel Pérez-Rodriguez, Juan Pedro Bolívar, Antonio Morillo, Javier Vigara, Rosa Léon. Exploring the microbial community inhabiting the phosphogypsum stacksof Huelva (SW, SPAIN) by a high throughput 16S/18S rDNA sequencing approach. Aquatic Toxicology. 2022. https://doi.org/10.1016/j.aquatox.2022.106103
2. Kaouther Sahli, Mohamed Amine Gomri, Julia Esclapez, Gómez-Villegas P., Bonete MJ, León R and Kharroub K. Characterization and biological activities of carotenoids produced by three haloarchaeal strains isolated from Algerian salt lakes. Archives of Microbiology (2022) 204:6. https://doi.org/10.1007/s00203-021-02611-0
3. Juan Cubero-Cardoso, Patricia Gómez‐Villegas María Santos-Martín Ana Sayago, Ángeles Fernández-Recamales, Rubén Fernández de Villarán A. A. Cuadri José Enrique Martín-Alfonso Rafael Borja Fernando González Fermoso Rosa León Juan Urbano Combining vegetable oils and bioactive compounds via inverse vulcanization for antioxidant and antimicrobial materials. Polymer Testing 2022. Volume 109, May 2022, 107546
4. Patricia Gómez-Villegas, José Luis Guerrero, Miguel Pérez-Rodríguez, Juan Pedro Bolivar, Javier Vigara, Rosa León. Metabarcoding data of prokaryotes and eukaryotes inhabiting the phosphogypsum stockpiles of the Odiel Marshlands in Huelva (S W, SPAIN). Data in brief. 41. 107989, 2022. https://doi.org/10.1016/j.dib.2022.107989
5. Rengel Rocío, Inmaculada Giraldez, Manuel J. Díaz, Trinidad García, Javier Vigara, Rosa Léon,*. Simultaneous production of carotenoids and chemical building blocks precursors from chlorophyta microalgae. Bioresource Technol. 2022 https://doi.org/10.1016/j.biortech.2022.127035
6. Umaima Al Hoqani, Rosa Leon, Saul Purton: Over-expression of a cyanobacterial gene for 1-deoxy-D-xylulose-5-phosphate synthase in the chloroplast of Chlamydomonas reinhardtii perturbs chlorophyll:carotenoid ratios. Journal of King Saud University – Science 2022. https://doi.org/10.1016/j.jksus.2022.102141
7. Sanjeet Mehariya, Martin Plöhn, Antonio León-Vaz, Alok Patel, Christiane Funk. Improving the content of high value compounds in Nordic Desmodesmus microalgal strains. Bioresource Technology, 359, 127455. (2022) https://doi.org/10.1016/j.biortech.2022.127445
2021
1. León-Vaz A, León R., Giráldez I., Vega JM., Vigara J. Impact of heavy metals in the microalga Chlorella sorokiniana and assessment of its potential use in cadmium bioremediation. Aquatic Toxicology239; 105941, 2021 (4.9, D1). https://doi.org/10.1016/j.aquatox.2021.105941
2. Valero Y, González-Fernández C, Cárdenas C, Guzmán F, León R, Cuesta. ANK-lysin peptides ameliorate viral encephalopathy and retinopathy disease and produce partial protection against nodavirus infection. Antiviral Research 2021, 532, 15, 2021. (4.1, Q1). https://doi.org/10.1016/j.aquaculture.2020.736035.
3.Constantino A; Rodrigues B., Leon R, Barros R, Raposo S. Alternative chemo-enzymatic hydrolysis strategy applied to different microalgae species for bioethanol production. Algal Research. 56, 102329. 2021. (4.0, Q1) https://doi.org/10.1016/j.algal.2021.102329
4.Cuesta A., Vila M, Molina-Marquez M, Carbajo C, Lebron JA, López-López M, López-Cornejo P, Moyá ML, López-Sanmartín M, López JR, Navas JJ., Vigara J, León R. Influence of adding terminal tags on the structural and antimicrobial properties of the peptide caerin 1.1. Aquaculture. 532, 15, 2021. (3.22, D1) https://doi.org/10.1016/j.aquaculture.2020.736035.
5.León-Vaz A, Romero LC, Gotor C, León R, Vigara J. Effect of cadmium in the microalga Chlorella sorokiniana: A proteomic study. Ecotoxicology and Environmental Safety 207 111301. 2021. (6.291, D1) DOI: 10.1016/j.ecoenv.2020.111301.
6. Gómez-Villegas, P.; Vigara, J.; Romero, L.; Gotor, C.; Raposo, S.; Gonçalves, B.; Léon, R. Biochemical Characterization of the Amylase Activity from the New Haloarchaeal Strain Haloarcula sp. HS Isolated in the Odiel Marshlands. Biology 2021, 10, 337.(3. 79, Q1) doi.org/10.3390/biology10040337
2020
1. Gómez‐Villegas P, J. Vigara, M. Vila, J. Varela, L. Barreira. and R. Léon. Antioxidant, Antimicrobial, and Bioactive Potential of Two New Haloarchaeal Strains Isolated from Odiel Salterns (Southwest Spain). Biology 2020, 9, 298. (3. 79, Q1); doi:10.3390/biology9090298
2. León R, Ruiz M, Valero Y, Cárdenas C, Guzman F, Vila M, Cuesta A. Exploring small cationic peptides of different origin as potential antimicrobial agents in aquaculture. Fish Shellfish Immunol. 2020, 98: 720-727. IF: 3.30, Q1. DOI:10.1016/j.fsi.2019.11.019.
3. Kaouther Sahli, Mohamed A. Gomri, Julia Esclapez, Patricia Gomez‐Villegas, Oulaya Ghennai, Maria‐Jose Bonete, Rosa Leon, Karima Kharrou. Bioprospecting and characterization of pigmented halophilic archaeal strains from Algerian hypersaline environments with analysis of carotenoids produced by Halorubrum sp. BS2. J. Basic Microbiology. 2020. DOI: 10.1002/jobm.202000083
4. Lisa M. Schüler, Paulo Duarte, Chloé Placines, Ana María Molina Márquez, Rosa Léon-Bañares, Katkam N. Gangadhar, João Varela and Luísa Barreira. Improvement of carotenoid extraction from a recently isolated, robust microalga, Tetraselmis sp. CTP4 (Chlorophyta). Bioprocess and Biosystems Engineering. 2020, 1-12. DOI: https://doi:10.1007/s00449-019-02273-9
5. Molina-Márquez a, Vila M, Rengel R, Fernández E, Garcia-Maroto F, Vigara J, León R. Validation of a New Multicistronic Plasmid for the Efficient and Stable Expression of Transgenes in Microalgae, 2020, Int. J. Mol. Sci. 21(3), 718. DOI: https://doi.org/10.3390/ijms21030718
2019
1. León-Vaz A León R., Díaz-Santos E., Vigara J., Raposo S. Using agro-industrial wastes for mixotrophic growth and lipids production by the green microalga Chlorella sorokiniana. New Biotechnology.51: 31-38 (2019).DOI: https://doi.org/10.1016/j.nbt.2019.02.001
2. Ana Molina-Márquez, Marta Vila, Javier Vigara, Ana Borrero and Rosa León. The Bacterial Phytoene Desaturase-Encoding Gene (CRTI) is an Efficient Selectable Marker for the Genetic Transformation of Eukaryotic Microalgae. Metabolites. 9, 49 (2019). DOI: doi:10.3390/metabo9030049
2018
1. Patricia Gómez-Villegas, Javier Vigara and Rosa León. Characterization of the Microbial Population Inhabiting a Solar Saltern Pond of the Odiel Marshlands (SW Spain). Mar. Drugs. 2018, 16, 332. DOI: https://doi.org/10.3390/md16090332
2. Rengel R, Smith RT, Haslam R, Sayanova O, Vila M, León R. Overexpression of acetyl-CoA synthetase (ACS) enhances the biosynthesis of neutral lipids and starch in the green microalga Chlamydomonas reinhardtii. Algal Research. 31: 183-193 (2018).
2017
1. Schüler LM., Peter S.C. Schulze, Hugo Pereira, Luísa Barreira, Rosa León and João Varela. Trends and strategies to enhance carotenoid, TAG and LC-PUFA production in microalgae. Algal Research. 25: 263–273 (2017) (3.99, Q1).
2016
1. Valverde F., Romero-Campereo FJ., León R., García-Guerrero M. and Serrano A. New Challenges in microalgal biotechnology Eur. J. protistol. 55:91-105 (2016). (2.58, Q2).
2. Díaz-Santos E., Vila M., Vigara J.,León R A new approach to express transgenes in microalgae and its use to increase the flocculation ability of Chlamydomonas reinhardtii J. Appl. Phycol. 28:1611-1621 (2016). (2.56, Q1).
3. De la Vega M.; Sayago A., García-Barneto A.; Ariza J and León R. Isolation of a new bacterioruberin-producing haloarchaea from the marshlands of the Odiel river in the Southwest Spain Biotechnol. progr. 32(3):592-600 (2016). (2.15, Q1).
2015
1. Varela, JC; Pereira H, Vila M, León R. Production of carotenoids by microalgae: achievements and challenges. Photosynth. Res. 125(3):423-36 (2015). (3.5, Q1).
2. Díaz-Santos E, Vila M, de la Vega M, León R, Vigara J. Study of bioflocculation Induced by Saccharomyces bayanus var. uvarum and flocculating protein factors in microalgae. Algae Research. 8: 23–29 (2015). (4.01, Q1).
2013
1. Díaz-Santos E., Vega M.,Vila M., Vigara J., León R. Efficiency of different heterologous promoters in the microalga C. reinhardtii. Biotechnol. Prog. 29(2):319-28 (2013).(2.34, Q1).
2012
1. Vila M., Díaz E., de la Vega M., Rodríguez H., Vargas A., León R. Promoter trapping in microalgae by inverse PCR using paromomycin as selective agent. Marine Drugs 10: 2749-2765 (2012). (3.85, Q1).
2011
1. M de la Vega; E. Díaz, M Vila and R León. Isolation of a new strain of Picochlorum sp and characterization of its potential biotechnological applications. Biotechnol. Prog. 27(6):1535-43 (2011). (2.34, Q1).
2. Cordero BF, Couso I, León R, Rodríguez H, Vargas MA. Enhancement of carotenoids biosynthesis in C. reinhardtii by nuclear transformation using a phytoene synthase gene isolated from C. zofingiensis. Appl. Microb. Biotechnol. 91(2):341-51 (2011). (3.43, Q1).
3. Couso, M Vila , H Rodríguez, M Vargas and R León. Overexpression of an exogenous phytoene synthase gene in the unicellular alga Chlamydomonas reinhardtii leads to an increase in the content of carotenoids. Biotechnol. Prog. 27(1):54-60 ( 2011). (2.34, Q1).
2010
1. BF Cordero, I Obraztsova, L Martín, I Couso, R León, MA Vargas and H Rodríguez. Isolation and characterization of a lycopene β-cyclase gene from Chlorella zofingiensis. J. Phycol. 46(6): 1229-1236 (2010). (2.24, Q1).
2008
1. M. Vila, I. Couso and R. León. Carotenoid content in mutants of the chlorophyte Chlamydomonas reinhardtii with low expression levels of phytoene desaturase. Process Biochem. 42:1147-1152 (2008). (2.4, Q1).