© 2017 American Physical Society. We unify two widely different approaches to understanding the infrared behavior of quantum chromodynamics (QCD), one essentially phenomenological, based on data, and the other computational, realized via quantum field equations in the continuum theory. Using the latter, we explain and calculate a process-independent running coupling for QCD, a new type of effective charge that is an analogue of the Gell-Mann-Low effective coupling in quantum electrodynamics. The result is almost identical to the process-dependent effective charge defined via the Bjorken sum rule, which provides one of the most basic constraints on our knowledge of nucleon spin structure. This reveals the Bjorken sum to be a near direct means by which to gain empirical insight into QCD's Gell-Mann-Low effective charge.